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Dimethyl Sulfoxide (DMSO)
Solubility Data
Bulletin # 102B
Introduction
DMSO, one of the strongest organic solvents, has been used commercially for
over forty years. It is an effective solvent for a wide array of organic materials,
including many polymers. DMSO also dissolves many inorganic salts, particularly
transition metals nitrates, cyanides and dichromates. DMSO is miscible with waterand most organic liquids.
This bulletin summarizes solubility of the following materials in DMSO:
Organics (pages 2-3)
Active pharmaceutical Ingredients (pages 4-6)
Resins and polymers (pages 8-10)
Inorganics (pages 10-11)
Gases (page 12)
Pharmaceutical Excipient Solubility Data (pages 16-17)

Oct 2007
Gaylord Chemical Company,
L.L.C. (GCC) is the world’s
leading provider of DimethylSulfoxide (DMSO) solutions.
Beginning in the early
1960’s ,GCC has been dedicated
to the development of new uses
for DMSO. In order to meet
customer-specific needs, GCC
has pioneered the development
of multiple grades of DMSO,
including DMSO USP.

Gaylord Chemical’s solutionsbased approach has contributed
to the development and growth of
New! DMSO Gel Preparation Data (pages 18-19)industries including
pharmaceuticals, hydrocarbons,
electronics, polymers, coatings,
Data related to the solvent properties of DMSO are given in tables on the following agricultural chemicals, and
pages:
industrial cleaners.
Relative Hansen Solubility Parameter Data (page 12)
Gaylord Chemical’s headquarters
Suggested DMSO Formulations for Industrial Solvent Replacement (page 14)
arelocated in Slidell, Louisiana
Hansen Solubility Parameter Data for Selected Polymers (page 14)
with manufacturing, research,
Solubility of Selected Polymers in DMSO / Tetralin mixtures (pages 14-15)
and development facilities in
Solubility of Selected Polymers in DMSO / MIBK mixtures (page 15)
nearby Bogalusa, Louisiana.
Appendix: Using Three Component Solubility Parameter Methodology in
GCCremains the only producer
Formulating Industrial Solvent Mixtures (Page 16)

of DMSO in the Western
Hemisphere.

Gaylord Chemical Company, L.L.C.
Your Global Leader For DMSO Solutions!

P.O. Box 1209
Slidell, LA 70459-1209 USA
1.800.426.6620 Office
1.985.649.0068 Fax
info@gaylordchemical.com

Table 1

Solubility of Organic Materials in DMSO
Solubility
Grams/100 cc DMSOMaterial
Acetic acid
Acetone
Acrawax
Acrawax B
Aniline
Anthracene
Beeswax

20-30°C
Miscible
Miscible
1
4
100

Carbon tetrachloride

Miscible

n-Dodecane

0.38

Carbowax 600

Miscible

Dodecylbenzene (Neolene 400)

3.5

Carbowax 6000
Carnauba wax

Insoluble

Castor oil
Ceresin wax
Chloroform

Miscible

Chlorosulfonic acid

Miscible

Very soluble

CarbonCarbon disulfide

100
Rosin soap (Hercules Dresinate X) Slightly soluble
Sevin
50

Succinic acid
Sugar (sucrose)
Sulfamic acid
Sulfuric acid
Tallow
Tallow amide, hydrogenated
(Armour Armide HT)
Terephthalic acid

30
30
40
Miscible
Insoluble

Tetra hydrophthaIic anhydride
Tetralin
Tetrapropylene
Thiourea
Toluene
Toluene di-isocyanate

50
Miscible
1
40
MiscibleMiscible

Tributylamine
Tricresyl phosphate
Triethanolamine laurylsulfate
Triethanolamine
Triethylamine
Trinitrotoluene
Turpentine
Urea

0.9
Miscible
Soluble
Miscible
10
Soluble
10
40

Xylene

Miscible

Insoluble
26

100

1.9
> 40
33

85

110

3

Table 2

Solubilities of Active Pharmaceutical Ingredients in DMSO
Pharmaceutical Nomenclature

CAS NumberSolubility
g/100ml
DMSO@25oC

Solubility
g/100g
DMSO@25oC

Solubility
g/100ml
Solution@25oC

103-90-2

84.3

77.0

43.5

Acetyl-D-Glucosamine

10036-64-3

4.9

4.5

4.3

Acyclovir USP

59277-89-3

15.4

14.0

12.3

0.6

0.5

0.5

N/A

20.4

18.6

15.7

Aamitriptyline Hydrochloride USP

549-18-8

25.4

23.2

18.8

Amphotericin B USP...
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