infec es

Jornal de Pediatria - Vol. 79, Nº2, 2003 141

0021-7557/03/79-02/141

Jornal de Pediatria
Copyright © 2003 by Sociedade Brasileira de Pediatria

ARTIGO ORIGINAL

Avaliação dos fatores associados a infecções recorrentes e/ou graves em pacientes com síndrome de Down
Evaluation of factors associated with recurrent and/or severe infections in patients with Down´s syndrome
Luciana M.A. Ribeiro1, Cristina M.A. Jacob2, Antonio C. Pastorino3,
Chong A.E. Kim4, Ângela B.F. Fomin3, Ana Paula B.M. Castro3

Resumo

Abstract

Objetivos: avaliar as características epidemiológicas, clínicas e laboratoriais de pacientes com síndrome de Down e infecções recorrentes e/ou graves, bem como avaliar a presença de imunodeficiência nesta população.

Objectives: to evaluate epidemiological, clinical and laboratorial aspects of patients with Down syndrome, who present recurrent and/ or severe infections, as well as to evaluate the presence of immunodeficiency in this population.

Métodos: foram avaliados, através de protocolo epidemiológico, clínico e laboratorial, incluindo aspectos imunológicos, pacientes com diagnóstico de síndrome de Down, através de estudo cromossômico, com queixa de infecções recorrentes e/ou graves, acompanhados no Ambulatório de Alergia e Imunologia do Departamento de Pediatria da FMUSP, no período de 1990 a 1999.

Methods: patients with Down syndrome diagnosed by chromosome analysis with recurrent and/or severe infections, followed at the Allergy and Immunology Unit of Children’s Institute from 1990 to 1999, were submitted to an epidemiological, clinical and laboratorial protocol, including immunological aspects.
Results: sex distribution was 1.6 M:1 F, with age ranging from
1 to 12 years and 10 months (average = 2y7m). Forty patients reported recurrent infections and five, sepsis. Out of all patients with recurrent infection, 31 fulfilled the repeated infection criteria, with pneumonia and rhinopharyngitis as the most common infections.
Congenital heart diseases