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Instrumental evaluation of stretch marks by in vivo confocal Raman Spectroscopy
K. Araujoa, Souzaa, D. Isenseea, E. Bagatinb, P.F.C Menezesc, V.V. Silvac, B.B. Swinkab, C.A.Brohemb, M.Lorencinib,d, I.H.S. Fefermanb,d and A. A Martina
aLaboratory of Biomedical Vibrational Spectroscopy – UNIVAP- Av. Shishima Hifumi, São José dos Campos, SP, 12200-00, Brazil
bUNIFESP - UniversidadeFederal de São Paulo, Departamento de Dermatologia,São Paulo – SP - Brazil.
c Grupo Boticário – Pesquisa Tecnológica - Av. Rui Barbosa 3450 - Afonso Pena
83055-900 – São José dos Pinhais, BrazildSKINGEN - Av. Rui Barbosa 3450 - Afonso Pena
83055-900 – São José dos Pinhais, Brazil

The skin's appearance is related to biochemical changes in their constituents, which may cause anincrease or decrease of the extracellular matrix, disruption of elastic fibers, changing the activity of fibroblasts and decreased collagen synthesis. Initially, stretch marks are inflammatory lesions, butthat progress to atrophy, making an aesthetic condition with a negative impact on life quality. Its causes are unclear, and there are only a few hypotheses. The acute phase is characterized byinflammation, when stretch marks are red and slightly raised in the sub-acute phase the stretch marks are purpura and chronic phase are atrophic and hypo chromic. The techniques commonly used in the study ofstretch marks are the tape stripping and biopsy followed by histopathological examination. Both are minimally invasive and do not provide information about the biochemical changes involved. In ourprevious study of histopatological evaluation in stretch marks we have used kin fragments obtained from plastic surgery selected by the presence or absence of stretch marks and then cut into fragmentsof 0.5 x 0.5cm. After cutting, the fragments were washed 1x with PBS (Sigma D1408) with 10x antibiotics penicillin / streptomycin (Gibco, 15 070). After washing the fragments, they were placed into...