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Botulinum toxin type A therapy for cervical dystonia (Review)
Costa J, Espírito-Santo C, Borges A, Ferreira JJ, Coelho M, Moore P, Sampaio C

This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library
2008, Issue 4
http://www.thecochranelibrary.com

Botulinum toxin type A therapy for cervical dystonia (Review)Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd

1

TABLE OF CONTENTS
ABSTRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
PLAIN LANGUAGE SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
OBJECTIVES . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . .
CRITERIA FOR CONSIDERING STUDIES FOR THIS REVIEW . . . . . . . . . . . . . . . . . .
SEARCH METHODS FOR IDENTIFICATION OF STUDIES . . . . . . . . . . . . . . . . . . .
METHODS OF THE REVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
DESCRIPTION OF STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
METHODOLOGICALQUALITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
RESULTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
AUTHORS’ CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
POTENTIAL CONFLICT OF INTEREST . . . . . . . . . . . . . . . . . . . . . .. . . . .
SOURCES OF SUPPORT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Characteristics of included studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Characteristics of excluded studies. . . . . . . . . . . . . . . . . . . . . . . . . . . . .
ADDITIONAL TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Table 01. Summary of Studies Included - Methods and Participants . . . . . . . . . . . . . . . . .
Table 02. Summary of Studies Included - Drug administration . . . . . . . . . . . . . . . . . . .
ANALYSES . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . .
Comparison 01. Objective Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . .
Comparison 02. Patient Subjective Assessment . . . . . . . . . . . . . . . . . . . . . . . . .
Comparison 03. Physician Subjective Assessment . . . . . . . . . . . . . . . . . . . . . . . .
Comparison 04. Pain relief . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..
Comparison 05. Side Effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Comparison 06. Objective Assessment (Subgroup analysis based on BtA dose) . . . . . . . . . . . . . .
Comparison 07. Patient Subjective Assessment (Subgroup analysis based on BtA dose) . . . . . . . . . . .
Comparison 08. Physician Subjective Assessment (Subgroup analysis based on BtA dose) . . . . . .. . . .
Comparison 09. Pain relief (Subgroup analysis based on BtA dose) . . . . . . . . . . . . . . . . . .
Comparison 10. Side Effects (Subgroup analysis based on BtA dose) . . . . . . . . . . . . . . . . .
INDEX TERMS
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COVER SHEET . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
GRAPHS AND OTHER TABLES . . . . . . . . . . . . . .. . . . . . . . . . . . . . . .
Analysis 01.01. Comparison 01 Objective Assessment, Outcome 01 Improvement of at least one point in Tsui Scale
Analysis 01.02. Comparison 01 Objective Assessment, Outcome 02 Improvement of at least three points in Tsui Scale
Analysis 01.03. Comparison 01 Objective Assessment, Outcome 03 Any improvement in any scale . . . . . .
Analysis 01.04. Comparison 01...
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