Case Report Clinical Pathology
Sialadenoma papilliferum: immunohistochemical study
´ A. P. N. Gomes, A. P. V. Sobral, S. V. L. Loducca, V. C. de Araujo:Sialadenoma papilliferum: immunohistochemical study. Int. J. Oral Maxillofac. Surg. 2004; 33: 621–624. # 2004International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Abstract. Sialadenoma papilliferum (SP) is a rare benign tumour of salivary gland origin, which has been included among the ductal papillomas in the latest classiﬁcation of tumours by the World Health Organisation. Two SP from the minor salivary gland of the palate of middle age patientswere presented and studied by immunohistochemical. Our results showed presence of cytokeratins (CKs) 13, 14, 7, 8, 19 and absence of vimentin and smooth muscle actin. This immunoproﬁle is similar to the excretory duct of salivary gland.
A. P. N. Gomes1, A. P. V. Sobral2, ´ S. V. L. Loducca3, V. C. de Araujo3
1 Department of Oral Pathology, School of Dentistry, University of Pelotas, Pelotas,Brazil; 2Department of Oral Pathology, School of Dentistry, University of Pernambuco, Pernambuco, Brazil; 3Department of Oral Pathology, School of Dentistry, Faculdade de ˜ Odontologia, University of Sao Paulo, Av. Prof Lineu Prestes, 2227, CEP: 05508-900, ˜ Sao Paulo, SP Brazil ,
Key words: salivary gland tumours; sialadenoma papilliferum; ductal papillomas; cytokeratin. Accepted forpublication 17 October 2003 Available online 6 February 2004
Sialadenoma papilliferum (SP) is a rare benign tumour of salivary gland origin ﬁrst reported in the literature by ABRAMS & FINCK in 19691. This name was proposed based on its gross and microscopic appearances, which closely resembled those of the syringocystadenoma papilliferum of the sweat gland. The tumour, which has been included among theductal papillomas in the latest classiﬁcation of tumours by the World Health Organization11, shows typical histopathological features: the deep areas of the tumour show an adenoid proliferation of duct-like structures lined by a double layer of luminal columnar cells and basal cuboidal or ﬂattened cells, which frequently forms papillary fronds. The superﬁcial part of the tumour exhibits verrucoidacanthotic hyperplasia of the epithelium, which is in continuity with the glandular epithelium of the duct-like structures. Clinically SP is a painless exophytic or papillary growth, usually found on the posterior hard palate of the adult male14. The exact histogenesis of SP has not been fully clariﬁed: some authors pro0901-5027/060621 + 04 $30.00/0
posed the origin of SP from intercalatedsalivary ducts12, others sustained the pluripotential basal cell4 or the cells of excretory ducts as the cells of origin of this tumour3,5. In the present investigation we used cytokeratins (CKs) of different molecular weights to examine by means of immunohistochemistry the antigenic proﬁle of this unusual tumour, intending to compare it with the immunoproﬁle seen in the different segments of thenormal salivary gland.
papilloma or vascular lesion, and the tissue submitted to pathologic examination.
A 52-year-old white woman had noticed a small exophytic growth on soft palate, which was ﬁrst noticed for 4 years. The tumour had a diameter of 5 mm and its consistency was ﬁrm. The pedunculated lesion was removed under local anaesthesia with clinical hypothesisof ﬁbrous polyp and the tissue was submitted to histologic evaluation.
Materials and methods
A 53-year-old white male was seen for an exophytic growth on the posterior hard palate lateral to midline. The lesion was present for about 3 years with no symptoms during its curse although it was below of denture. The tumour was 10 mm in diameter, reddish in colour and pedunculated. Its surface...