Bacterial larvicidas

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DRAFT Guideline specifications for bacterial larvicides for public health use
Report of the WHO Informal Consultation 28-30 April 1999 WHO, Geneva

World Health Organization Communicable Diseases Prevention and Control WHO Pesticide Evaluation Scheme (WHOPES)

This document is not issued to the general public, and all rights arereserved by the World Health Organization (WHO). The document may not be reviewed, abstracted, quoted, reproduced or translated, in part or in whole, without the prior written permission of WHO. No part of this document may be stored in a retrieval system or transmitted in any form or by any means – electronic, mechanical or other – without the prior written permission of WHO.



Introduction Role of Bacterial Larvicides in Public Health 2.1 2.2 2.3 2.4 Current Uses Integrated Control Potential for Resistance Future Prospects for Bacterial Larvicides

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Registration Requirements, Including Quality Control and Safety Requirements for Bacterial Larvicides Guideline Specifications for Bacterial Larvicides 4.1. Technical and Formulation-SpecificRequirements and Objectives for Their Inclusion in the Specifications 4.1.1 Description of the Product 4.1.2 Active Ingredient 4.1.3 Physical and Physico-chemical Properties 4.1.4 Packaging 4.1.5 Labelling Guideline Specifications for Technical Concentrate and Common Formulations of Bacterial Larvicides 4.2.1 4.2.2 4.2.3 4.2.4 4.2.5 Technical Concentrate (TK) Aqueous Suspension Concentrate (SC) WaterDispersible Granule (WG) Wettable Powder (WP) Water Dispersible Tablet (WT)


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5. 6.

Recommendations Annex 1. Determination of the toxicity of Bacillus thuringiensis subsp. israelensis and B. sphaericus Products Annex 2. List of Participants





Dr Arata Kochi, theDirector of the Communicable Diseases Prevention and Control of WHO, on behalf of the Director-General opened the Consultation. Dr Kochi noted that the increasing production and demand for bacterial larvicides, especially Bacillus thuringiensis israelensis (Bti), would require internationally agreed guideline specifications and test methods which would assure the production of efficient and safelarvicide products, protecting both consumers and manufacturer. Such guidelines would also promote the harmonization of relevant national standards and thus, world trade in such pesticides. He added that the WHO Pesticide Evaluation Scheme (WHOPES), an international programme which co-ordinates the testing and evaluation of pesticides for public health use, publishes specifications for pesticides tobe used as part of the International Code of Conduct on Distribution and Use of Pesticides. Dr Kochi informed the participants that WHOPES has been traditionally testing/evaluating chemical pesticides for vector control, but is now planning to expand its activities to include a greater variety of pests and pesticides, including microbial larvicides. Dr M. Zaim, scientist in charge of WHOPES,presented an overview of the Scheme and elaborated on the objectives and the work plan of the meeting. He stated the objective of the meeting as to prepare draft guideline specifications for bacterial larvicides, i.e., Bti and B. sphaericus (Bsph), for consideration by the WHO Expert Committee on Vector Biology and Control “Chemistry and specifications of pesticides”. This Expert Committee couldrecommend their adoption by the World Health Assembly and subsequent publication as official WHO specifications. The meeting was attended by 3 representatives of national registration authorities, the German Mosquito Control Association, 7 scientists, 9 representatives of industry, representatives of the Food and Agriculture Organization of United Nation (FAO) and the United Nations Environmental...