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Elsevier Editorial System(tm) for Nutrition Research Manuscript Draft Manuscript Number: NR-12-29 Title: Protein restriction after weaning modifies the calcium transient and induces single left ventricular cardiomyocytes contractile dysfunction in rats Article Type: Short Communication Corresponding Author: Dr. Antônio J. Natali, Corresponding Author's Institution: Federal University of ViçosaFirst Author: Arlete R Penitente Order of Authors: Arlete R Penitente; Rômulo Dias Novaes; Deoclécio A Chianca-Jr; Márcia F da Silva; Marcelo E Silva; Amanda M. A Souza; Silvia Guatimosim; Pedro W. M Almeida; Márcia N. M Alves; Leonardo B Felix; Clóvis A Neves; Antônio J Natali

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Protein restriction after weaning modifies the calcium transient and induces
single left cardiomyocytescontractile dysfunction in rats

Antônio José Natali

Arlete Rita Penitente X
March, 2012

Federal University of Viçosa

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MINISTÉRIO DA EDUCAÇÃO
FEDERAL UNIVERSITY OF VIÇOSA

VIÇOSA – MG – BRAZIL

Dear Prof. Bruce A. Watkins, Editor-in-Chief Nutrition Research Dear Editor,

Please find enclosed the original paper entitled “Protein restriction after weaning modifies the calciumtransient and induces single left ventricular cardiomyocytes contractile dysfunction in rats” by Penitente et al. to be considered for publication in this prestigious journal. Protein restriction is associated with cardiovascular diseases. However, several aspects of the cellular and molecular basis of these diseases remain to be clarified. Up to date, there are no data in the literature showingthese deleterious ventricular mechanical functional changes in response to protein restriction at the cellular level. In the present study, we identified that protein restriction induced a marked morphological reorganization of the left ventricular cardiomyocytes in rats. Interestingly, these changes occurred simultaneously with cardiomyocytes contractile dysfunction and attenuation in theintracellular calcium transient. Taken together, these findings suggest that morphofunctional pathological adaptations of the left ventricular cardiomyocytes may constitute an additional factor in the pathophysiology of cardiovascular diseases associated with protein restriction.

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The content of the manuscript is original and has not been published or accepted for publication elsewhere, either inwhole or in part. Additionally, it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere including electronically in the same form, in English or in any other language, without the written consent of thecopyright-holder. The authors do not have any conflict of interest regarding this paper, have seen and approved the content and submission of this manuscript and have contributed significantly to the work. The experimental protocols were approved by the Ethics committee of the Federal University of Ouro Preto (protocol 30/2009). Information included in the manuscript, page 5, lines 86 and 87.Sincerely, Antônio J. Natali, PhD.

*Corresponding author: Antônio J. Natali, PhD. Federal University of Viçosa, DES, Av. Peter Henry Rolfs, s/nº, Zip code: 35.570-000. Viçosa-MG, Brazil. Phone: +55 31 38994390. Fax: +55 31 3899 2249. E-mail address: anatali@ufv.br

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Protein restriction after weaning modifies the calciumtransient and induces single left ventricular cardiomyocytes contractile dysfunction in rats

Arlete R. Penitentea, Rômulo D. Novaesa, Deoclécio A. Chianca-Jrb, Márcia F. da Silvaa, Marcelo E. Silvab, Amanda M.A. Souza b, Silvia Guatimosimc, Pedro W.M. Almeidac, Márcia N.M. Alvesc, Leonardo B. Felix d, Clóvis A. Nevesa, Antônio J. Natalie,*

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Department of General Biology, Federal University...
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