O papel das proteínas da matriz extracelular e das metaloproteinases em carcinomas de cabeça e pescoço: uma atualização bibliográfica
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Rev Bras Otorrinolaringol.V.71, n.1, 81-6, jan./fev. 2005
ARTIGO DE REVISÃO
REVIEW ARTICLE
O papel das proteínas da matriz extracelular e das metaloproteinases em carcinomas de cabeça e pescoço: uma atualização bibliográfica
The role of extracellular proteins matrix and the metalloproteinases in head and neck carcinomas: an update review
Antonio L.A. Pereira1, Simone S.L. Veras2, Éricka
J.D. Silveira3, Flávio R.G. Seabra4, Leão Pereira Pinto5, Lélia B. Souza6, Roseana A Freitas6
Palavras-chave: carcinoma, cabeça e pescoço, matriz extracelular, metaloproteinases.
Key words: head and neck, carcinoma, matrix extracellular, metalloproteinases.
Resumo / Summary
I
I
nteractions involving tumor cells and the extracellular matrix (ECM) strongly influence tumor development, including that situated in head and neck, affecting cell proliferation and survival, as well as the ability to migrate beyond the original location into other tissues to form metastases. These cell migration is often facilitated by a partial destruction of the surrounding
ECM, which is catalyzed by matrix metalloproteinases
(MMPs), a family of more than 20 endopeptidasis, that is controlled by regulated expression of specific inhibitors (TIMPs). Several studies of ECM and MMPs markers have been provide additional diagnostic and prognostic information in head and neck carcinomas.
In this review, we are considering the role of ECM and
MMPs in tumor progression, emphasizing its proteolytic contributors to this process, and interactions between several members of ECM providing substract to regulation of this process.
nterações entre células neoplásicas e constituintes da matriz extracelular (MEC) interferem fortemente no desenvolvimento tumoral, incluindo os localizados em cabeça e pescoço, pois influenciam a proliferação e sobrevivência celular, bem como a sua capacidade de migrar do sítio primário para outros tecidos e formar metástases.