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REVISTA BRASILEIRA DE TOXICOLOGIA BRAZILIAN JOURNAL OF TOXICOLOGY

©SOCIEDADE BRASILEIRA DE TOXICOLOGIA

Revista Brasileira de Toxicologia 21, n.2 (2008) 49-59

Fitoterápicos e potenciais interações medicamentosas na terapia do câncer
Heidge Fukumasu1,2,3*, Andreia Oliveira Latorre1, Natalia Bracci3, Silvana Lima Górniak1, Maria Lucia Zaidan Dagli1
1

Laboratório de Oncologia Experimental e Comparada, Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brasil. 2Departamento de Ciências Básicas, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga, SP, Brasil. 3RBR Regulamentação e Registro, São Paulo, SP, Brasil

ABSTRACT

Possible herb-drug interactions in cancer treatment Cancer treatment has been considered one of the most challenging problems of modern medicine. From the moment that the primary tumor metastasizes through the body, the prognoses turns to poor and the chemotherapy is considered the main choice of treatment in this stage. One positive point of chemotherapy is the access to the majority of metastasis. Yet, it presents several disadvantages frequently related to adverse effects, since a great number of chemotherapeutic drugs present a low therapeutic dosage, generally close to the toxic dose. On the other hand, several natural products have emerged to treat cancer, increasing their consumption in the western world. Although some plants have demonstrated antitumoral effects in preclinical models, one key problem is when these plants are consumed together with the prescribed conventional chemotherapy, possibly leading to herb-drug interactions. Our goal here is to alert that arbitrary or even prescribed consumption of these herb-based substances along with conventional chemotherapeutic drugs might generate herb-drug interactions, increasing the side-effects, toxicity or even decreasing the antineoplastic effect. We will discuss important