Neoplasia

Online Submissions: http://www.wjgnet.com/esps/ [e-mail] doi:10.3748/wjg.v19.i9.1451

World J Gastroenterol 2013 March 7; 19(9): 1451-1457 ISSN 1007-9327 (print) ISSN 2219-2840 (online)

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BRIEF ARTICLE

Decision making for pancreatic resection in patients with intraductal papillary mucinous neoplasms
Bin Xu, Wei-Xing Ding, Da-Yong Jin, Dan-Song Wang, Wen-Hui Lou
Bin Xu, Wei-Xing Ding, Department of General Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China Da-Yong Jin, Dan-Song Wang, Wen-Hui Lou, Department of General Surgery, Zhong Shan Hospital, Fudan University, Shanghai 200032, China Author contributions: Xu B and Ding WX contributed equally to this work; Xu B and Lou WH designed the research; Xu B, Ding WX, Jin DY, Wang DS and Lou WH performed the research; Ding WX, Jin DY and Lou WH analyzed the data; Xu B wrote the paper. Supported by The National Natural Science Foundation of China, No. 81001007; the Program for Young Excellent Talents in Tongji University, No. 2008KJ060; and Youth Fund of the Shanghai Tenth People’s Hospital, No. 10RQ105 Correspondence to: Wen-Hui Lou, MD, Department of General Surgery, Zhong Shan Hospital, Fudan University, Shanghai 200032, China. [e-mail] Telephone: + 86-21-64041990 Fax: [phone] Received: December 1, 2012 Revised: January 24, 2013 Accepted: February 5, 2013 Published online: March 7, 2013

resection was performed using significant factors from the univariate analysis. RESULTS: CT/MRI images, including main and mixed duct IPMNs, tumor size > 30 mm or a solid component appearance in the lesion, and preoperative serum CA19-9 > 37 U/mL had good predictive value for determining pancreatic resection (P < 0.05), but with limitations. Combining the above factors (CT/MRI images and CA19-9) improved the accuracy and sensitivity for determining pancreatic resection in IPMNs. Using ROC analysis, the