Guidelines hiv 2008

Guidelines for the Use of Antiretroviral
Agents in HIV-1-Infected
Adults and Adolescents
January 29, 2008

Developed by the DHHS Panel on
Antiretroviral Guidelines for Adults and Adolescents – A Working Group of the
Office of AIDS Research Advisory Council (OARAC)

How to Cite the Adult and Adolescent Guidelines:
Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents.
Department of Health and Human Services. January 29, 2008; 1-128. Available at http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.
Accessed (insert date) [insert page number, table number, etc. if applicable]
It is emphasized that concepts relevant to HIV management evolve rapidly. The Panel has a mechanism to update recommendations on a regular basis, and the most recent information is available on the
AIDSinfo Web site (http://AIDSinfo.nih.gov).

January 29, 2008

What’s New in the Document?
The following changes have been made to several sections of the December 1, 2007 version of the guidelines.

What to Start: Initial Combination Regimens for the Antiretroviral-Naïve Patient?
The Panel revised its recommendations for several “preferred” and “alternative” antiretroviral components for treatment-naïve patients:
“Abacavir + lamivudine” has been changed from “alternative” to “preferred” 2-NRTI component in patients who have tested negative for HLA-B*5701 (AII).
“Zidovudine + lamivudine” has been changed from “preferred” to “alternative” 2-NRTI component (BII).
“Ritonavir-boosted saquinavir” has been changed from a PI-option that was considered as “Acceptable as initial antiretroviral components but inferior to preferred or alternative components” to an “alternative” PI component (BII).
The following options are no longer recommended as components for initial therapy in treatment-naïve patients: o Nelfinavir as PI component o Stavudine + lamivudine as