Efetividade da suplementa o de sulfato ferroso na prevenen o de anemia em crian as

REVISÃO REVIEW

Efetividade da suplementação de sulfato ferroso na prevenção da anemia em crianças: revisão sistemática da literatura e metanálise
Effectiveness of ferrous sulfate supplementation in the prevention of anemia in children: a systematic literature review and meta-analysis
Eficacia del suplemento de sulfato ferroso en la prevención de la anemia en niños: revisión sistemática de la literatura y metaanálisis
Francieli Cembranel 1
Camila Dallazen 1
David Alejandro González-Chica

Universidade Federal de Santa Catarina,
Florianópolis, Brasil.

1

Correspondência
D. A. González-Chica
Programa de Pós-graduação em Nutrição, Universidade
Federal de Santa Catarina.
Campus Universitário
Trindade, Florianópolis, SC
88040-900, Brasil. [e-mail] 1

Abstract

Resumo

This was a systematic review and meta-analysis of studies evaluating the effectiveness of ferrous sulfate supplementation in the prevention of anemia in children under five. The database search included PubMed, Scopus, LILACS, and
SciELO. Articles published between 1980 and
2011 in Spanish, English, or Portuguese were included, using the keywords child, preschool, infant, anemia, prevention, and iron supplementation. The authors selected 13 studies, which showed that regardless of dose and duration of supplementation, daily regimen was more consistently related to improvement in hemoglobin levels (pooled effect 0.56mg/dL, 95%CI: 0.31;
0.81, p < 0.001) as compared to weekly intervention (pooled effect 0.28mg/dL, 95%CI: -0.22; 0.78, p = 0.273). Iron supplementation was not associated with decreased prevalence of anemia, even with daily doses, and administration with other micronutrients did not bring additional benefits compared to the exclusive administration of iron supplement. Daily supplementation of ferrous sulfate was more effective than weekly doses in improving hemoglobin levels.

Revisão sistemática e metanálise de estudos que avaliaram a efetividade da suplementação de sulfato