Clinical manifestations pcm

Title: Specific clinical presentation of Paracoccidioidomycosis in brazilian amazonia.

Authors:
Oliveira, R.E.N.N.
Barros, V.
Silva, R.L
Santos, S.B.
Silva, T.C
Romanholo, H.S.B.
Rodrigues, A.M.

Affiliation:
FACIMED, School of Medicine, Cacoal-Rondônia, Brazil.
UFMG. School of Medicine, Belo Horizonte-MG, Brazil.

Introduction:
Paracoccidioidomycosis is the most prevalent systemic mycosis in Brazil and an emergent tropical disease in Brazilian Amazon, with a significant morbidity and mortality. Recent descriptions had shown that Paracoccidioides species in this Brazilian region have different phenotypic and genotypic profile, but there are still few evidences of clinical aspects of this disease in our region.
Material and Methods:
We conduct an observational retrospective clinical study of cases treated in the Outpatient Specialized of the Cacoal – RO, southern Amazon in the period January 2000 to June 2010. The research was conducted by a retrospective study with a descriptive quantitative analysis through the 175 records available at the reference service.
Results:
The mean age of patients was 51.90 for men and 66.74 for women, the proportion man: woman is 13,5:1. More than half(53.72%) of patients were rural workers, and the remainder (47.28%) lived in urban areas and had different activities. The chronic form (adult form) prevailed in all patients (100%), less than other parts of Brazil (Mato Grosso do Sul – 84,6%, Brasilia – 77%). The main clinical form were pulmonary (62.85%), as in other parts of Brazil, but the incidence of Laryngeal disease(10,9%), skin(11,4%) and lymphatic(5,7%) disease were markedly less frequent than in other parts of Brazil .
Main Conclusions:
Besides different mycological characteristics, there are evidence in our case series that clinical manifestations of Paracoccidioidomycosis are not the same in Amazon as in other parts of Brazil. We notice none juvenile form in all our patients, and there are much less