Anatomia humana

Elsevier Editorial System(tm) for Nutrition Research Manuscript Draft Manuscript Number: NR-12-29 Title: Protein restriction after weaning modifies the calcium transient and induces single left ventricular cardiomyocytes contractile dysfunction in rats Article Type: Short Communication Corresponding Author: Dr. Antônio J. Natali, Corresponding Author's Institution: Federal University of Viçosa First Author: Arlete R Penitente Order of Authors: Arlete R Penitente; Rômulo Dias Novaes; Deoclécio A Chianca-Jr; Márcia F da Silva; Marcelo E Silva; Amanda M. A Souza; Silvia Guatimosim; Pedro W. M Almeida; Márcia N. M Alves; Leonardo B Felix; Clóvis A Neves; Antônio J Natali

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Protein restriction after weaning modifies the calcium transient and induces single left cardiomyocytes contractile dysfunction in rats

Antônio José Natali

Arlete Rita Penitente X
March, 2012

Federal University of Viçosa

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MINISTÉRIO DA EDUCAÇÃO
FEDERAL UNIVERSITY OF VIÇOSA

VIÇOSA – MG – BRAZIL

Dear Prof. Bruce A. Watkins, Editor-in-Chief Nutrition Research Dear Editor,

Please find enclosed the original paper entitled “Protein restriction after weaning modifies the calcium transient and induces single left ventricular cardiomyocytes contractile dysfunction in rats” by Penitente et al. to be considered for publication in this prestigious journal. Protein restriction is associated with cardiovascular diseases. However, several aspects of the cellular and molecular basis of these diseases remain to be clarified. Up to date, there are no data in the literature showing these deleterious ventricular mechanical functional changes in response to protein restriction at the cellular level. In the present study, we identified that protein restriction induced a marked morphological reorganization of the left ventricular cardiomyocytes in rats. Interestingly, these changes occurred simultaneously with cardiomyocytes contractile dysfunction and attenuation in the