Adjuvantes

04/27-03/116

Rev. bras. alerg. imunopatol.
Copyright © 2004 by SBAI

ARTIGO DE REVISÃO

Adjuvantes de vacinas: possibilidades de uso em seres humanos ou animais
Vacine adjuvants: possibilities for use in humans or animals
Fabíola C. B. e Resende1, Jean Passold2, Silvia I. A. C. Ferreira3,
Carlos R. Zanetti4, Hermênio C. Lima5
Abstract:
Objective: To systematically review the adjuvants used, to study the new substances with the aim of update the concepts of the use of these substances, which act together with the antigen, when in contact with the immunological system, and their use for human or animal vaccine.
Methods: A literature systematic review was accomplished based on Medline data bank starting from
1969. Original articles on adjuvants discussing inflammatory response, cellular immune response, humoral immune response, side-effects and protection aspects were selected.
Results: Original articles or book chapters were selected. We could observe that there are differences in the inflammatory capacity among the different adjuvants. These differences can result in some patterns of cellular and humoral immune responses, in agreement with cell which is more stimulated. Therefore, adjuvants which induce mononuclear activation seem to facilitate cellular and humoral response. A more granulocytic response can result in more local or systemic side-effects and can also be associated with a reduction of antigen capacity for the immune system stimuli. Conclusion: The animal or human immunological system behaves different when challenged with some adjuvants. Once the same mechanisms used by the organism for protection against infections can induce diseases, there is an important aspect in studying each adjuvant to be used in a particular situation. Moreover, there is a need of finding substances that can be

Resumo
Objetivo: Rever de forma sistemática as substâncias adjuvantes mais estudadas, utilizadas e as novas substâncias; com o intuito de atualizar os conceitos de