Neuro stroke

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A Novel, Self-Expanding, Nitinol Stent in Medically Refractory Intracranial Atherosclerotic Stenoses: The Wingspan Study Arani Bose, Marius Hartmann, Hans Henkes, Hon Man Liu, Michael M.H. Teng, Istvan Szikora, Ansgar Berlis, Jurgen Reul, Simon C.H. Yu, Michael Forsting, Matt Lui, Winston Lim and Siu Po Sit Stroke 2007;38;1531-1537; originally published online Mar 29, 2007; DOI:10.1161/STROKEAHA.106.477711
Stroke is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX 72514 Copyright © 2007 American Heart Association. All rights reserved. Print ISSN: 0039-2499. Online ISSN: 1524-4628

The online version of this article, along with updated information and services, is located on the World Wide Web at: Information about subscribing to Stroke is online at Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, a division of Wolters Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone: 410-528-4050. Fax: 410-528-8550. E-mail: Reprints: Information about reprints can be foundonline at

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A Novel, Self-Expanding, Nitinol Stent in Medically Refractory Intracranial Atherosclerotic Stenoses
The Wingspan Study
Arani Bose, MD; Marius Hartmann, MD, PhD; Hans Henkes, MD; Hon Man Liu, MD; Michael M.H. Teng, MD; Istvan Szikora, MD; Ansgar Berlis, MD; Jurgen Reul, MD; Simon C.H. Yu, MD;Michael Forsting, MD; Matt Lui, MD; Winston Lim, MD; Siu Po Sit, PhD
Background and Purpose—The purpose of this study was to assess the safety and performance of the Wingspan stent system and Gateway percutaneous transluminal angioplasty balloon catheter in the treatment of high-grade, intracranial atherosclerotic lesions in patients who had failed medical therapy. Methods—In this prospective,multicenter, single-arm study, medically refractory patients with a modified Rankin score 3 and recurrent symptoms attributable to angiographically demonstrated intracranial stenosis 50% in a vessel 2.5 to 4.5 mm in diameter were enrolled. Intracranial lesions were predilated with an undersized Gateway balloon catheter to 80% of the native vessel diameter, followed by deployment of the self-expandingWingspan stent to facilitate further remodeling of the atherosclerotic plaque and to maintain vessel patency. Neurologic examinations and angiograms were performed at 6 months after the procedure. Results—Among the 45 patients enrolled, the degree of stenosis was reduced from a baseline of 74.9 9.8% to 31.9 13.6% after stenting and 28 23.2% at the 6-month follow-up. The 30-day compositeipsilateral stroke/death rate was 4.5% (2/44); at the 6-month follow-up, the ipsilateral stroke/death rate was 7.0%, the rate for all strokes was 9.7%, and all-cause mortality was 2.3%. Physician-reported follow-up in 43 patients (average of 13 months) conducted outside the study protocol (not adjudicated by the clinical event committee) reported 1 additional ipsilateral stroke. Conclusions—In medicallyrefractory patients with high-grade intracranial atherosclerotic stenoses, a new treatment paradigm involving predilation with an undersized Gateway percutaneous transluminal angioplasty balloon catheter and placement of a self-expanding Wingspan stent system appears to be safe, may facilitate remodeling, and may contribute to favorable angiographic outcomes. (Stroke. 2007;38:1531-1537.) Key Words:atherosclerosis medical therapy nitinol stent stenosis stroke

t has been reported that intracranial (IC) atherosclerosis may be the underlying pathology in up to 15% of patients with ischemic stroke.1–5 Stroke prevention by open surgical vascular intervention in patients with extracranial atherosclerotic disease was demonstrated by a landmark study in symptomatic patients with stenosis 70% of...
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