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"Tuberculosis remains one of the most serious infectious diseases worldwide requiring new
tools to circumvent current molecular diagnostics limitations. Nanodiagnostics, i.e.
nanotechnology baseddiagnostics, may do just that by decreasing the time needed for the
molecular characterisation of the infecting agent, and allowing for miniaturisation and
portability for point-of-need adapted toremote regions without suitable lab equipment.
Introduction
Tuberculosis (TB) remains one of the most serious infectious diseases in the world
demanding new, fast, reliable and effective diagnostictools (World Health Organisation
[WHO], 2011). Several technological strategies have been proposed that rely on decreasing
the time needed for unequivocal molecular identification andcharacterisation of the infecting
agent. Nanotechnology has triggered the development of new, fast and cheap approaches for
biomolecular recognition that may circumvent some of the current limitations of molecularmethods for laboratory diagnostics of TB.
Nanodiagnostics can be defined as the use of nano-sized materials, devices or systems for
diagnostics purposes. Here, we shall provide an overview ofnanodiagnostics for
Mycobacterium tuberculosis (Mtb) detection and characterisation, and how it can contribute
for the early and accurate detection of TB. Current advances in nanofabrication may enablethe construction of cheap and full-automated devices, which may allow for point-of-need
Microbiologia
Portuguese Society for Microbiology Magazine
Nanoprobes for TB diagnostics | Microbiologiahttp://magazinespm.wordpress.com/2012/08/01/nanoprobes-tb/
1 de 8 30-08-2012 16:26
diagnostics.
Tuberculosis
By the end of the 1970’s, a global agreement reasoned that tuberculosis was at the edge ofbeing eliminated worldwide due to the idealistic “full effectiveness” of the anti-TB therapy,
especially in view of the promising results with therapy combining the two most effective
anti-TB...
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