Chronic ingestion different alcoholic drinks indduces different levels of hepatotoxicity

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Janjacomo G, dos Santos JM, Rosa CS, Rosa ML
Faculdade de Medicina de Catanduva-FPAIntroduction: The aim of this work was to investigate whether the liver is differently affected by chronic consumption of different types of usual alcoholic drinks. Methods: Ratswere treated with ethanol (E), sugar-cane liquor (S), vodka (V) or whisky (W) 5%-20%, increasing 5% per week (habituation), and 20% maintained for 15 days (chronic ingestion). Theanimals, control (C) and alcoholic (E, S, V or W) were deeply anesthetized, intracardially perfused, the livers removed and sectioned. Sections were stained by hematoxilin-eosin andevaluated by scoring for the presence of hepatic steatosis: type (macro or microvesicular), intensity (absent; low, < 1/3 of the cells; moderate, 2/3 of the cells or acentuated, >2/3 of the cells) and distribution (centrilobular, CL; mediozonal, MZ or periportal, PP). Results: Chronic ingestion of alcohol resulted in hepatic steatosis in all animalsirrespective of the drinks. Macro and microvesicular steatosis were seen in E, S and W rats while only microvesicular was observed in V rats. The intensity of the steatosis was notsignificantly different among the alcoholic groups (p=0.063, Kruskal-Wallis followed by Fisher test). Low to accentuated steatosis were induced by E and W while V induced low steatosis and Sinduced moderate steatosis. Rats treated with E, S or W presented CL, MZ and PP steatosis while rats treated with V showed only CL steatosis. Discussion: These results show thatchronic ingestion of different alcoholic drinks induces different levels of hepatotoxicity with ethanol inducing the grater alterations. Financial support: Fundação Padre Albino.
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