cabras e sua pelagem

Pesq. Vet. Bras. 33(7):867-872, julho 2013

Doença de depósito lisossomal induzida pelo consumo de
Ipomoea verbascoidea (Convolvulaceae) em caprinos no semiárido de Pernambuco1

Dayane D.C.C. Lima2, Raquel F. Albuquerque2, Brena P. Rocha3, Maria Edna G. Barros4,
Dale R. Gardner5, Rosane M.T. Medeiros6, Franklin Riet-Correa6 e Fábio S. Mendonça7*
ABSTRACT.- Lima D.D.C.C., Albuquerque R.F., Rocha B.P., Barros M.E.G., Gardner D.R., Medeiros R.M.T., Riet-Correa F. & Mendonça F.S. 2013. [Lysosomal storage disease induced by the consumption of Ipomoea verbascoidea (Convolvulaceae) in goats at northeastern
Brazil.] Doença de depósito lisossomal induzida pelo consumo de Ipomoea verbascoidea
(Convolvulaceae) em caprinos no semiárido de Pernambuco. Pesquisa Veterinária Brasileira 33(7):867-872. Departamento de Morfologia e Fisiologia Animal, Universidade Federal
Rural de Pernambuco, Rua Dom Manuel Medeiros s/n, Dois Irmãos, Recife, PE 52171-900,
Brazil. E-mail: [e-mail]
The aim of this paper was to reproduce the poisoning of Ipomoea verbascoidea in goats and describe the epidemiological, clinical and pathological aspects of spontaneous poisoning by this plant in Pernambuco. For this, we studied the epidemiology of the disease in seven municipalities in the semiarid region of the State. Three spontaneously poisoned goats were examined and then euthanized and necropsied (Group I). To reproduce the disease, the dried leaves of I. verbascoidea containing 0.02% swainsonine were supplied at doses of 4g/kg (0.8mg swainsonine/kg) to two groups of three animals. The goats in Group II received daily doses of the plant during 40 days and were euthanized on the 41st day of the experiment. Goats from
Group III received daily doses of the plant during 55 days and were euthanized on the 120th day of the experiment. Other three goats constituted the control group (Group IV). In experimental groups, the brain lesions were evaluated by histopathology;