Artigo Pra Resumir Da Prof Cida

Artigo pra resumir
Profª Cida
O ENTENDIMENTO DO METABOLISMO DO TUMOR E SEU POTENCIAL COMO ALVO PARA O TRATAMENTO DO CANCRO.
Ana Carolina Santos de Souza*,1, Alexandre Donizeti Martins Cavagis2,
Carmen Veríssima Ferreira3 and Giselle Zenker Justo4
1Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Rua
Santa Adélia, 166, 09.210-170, Santo André, SP, Brazil; 2Departamento de
Física, Química e Matemática (DFQM), Universidade Federal de São Carlos
(UFSCar), campus Sorocaba, Rodovia João Leme dos Santos, km 110, 18.052-
780, Sorocaba, SP, Brazil; 3Laboratório de Bioensaios e Transdução de Sinal,
Departamento de Bioquímica, Instituto de Biologia, Universidade Estadual de
Campinas (UNICAMP), 13.083-862, Campinas, SP, Brazil; 4Departamento de
Ciências Biológicas (campus Diadema) and Departamento de Bioquímica
(campus São Paulo), Universidade Federal de São Paulo (UNIFESP), Rua 3 de maio, 100, 04.044-020, São Paulo, SP, Brazil
Abstract: The role played by oncogenes and tumor suppressors in the genesis of cancer is well established. Considering that cancer cells are a product of genetic disorders that alter crucial intracellular signaling pathways associated with the regulation of survival, proliferation, differentiation and death mechanisms it is not surprising that traditional antitumor approaches target specific molecular players whose action/expression is altered in cancer cells. However, because the physiology of normal cells is controlled by the same signaling pathways that are disturbed in cancer cells many cancer therapies also cause important side effects and multidrug resistance, the main causes of therapy failure. Since the pioneering work of Otto Warburg, over 80 years ago, the subversion of normal cellular metabolism by cancer cells has been highlighted by many studies. In recent years, the study of tumor metabolism has received considerable attention because metabolic transformation is now recognized as a crucial cancer hallmark and a direct