1.2 3 Pin

PIM1
From Wikipedia, the free encyclopedia
Pim-1 oncogene

PDB rendering based on 1xqz.
Available structures
PDBOrtholog search: PDBe, RCSB
[show]List of PDB id codes
Identifiers
SymbolsPIM1; PIM
External IDsOMIM: 164960 MGI: 97584 HomoloGene: 11214 ChEMBL: 2147 GeneCards: PIM1 Gene
EC number2.7.11.1
[show]Gene Ontology
RNA expression pattern

More reference expression data
Orthologs
SpeciesHumanMouse
Entrez529218712
EnsemblENSG00000137193ENSMUSG00000024014
UniProtP11309P06803
RefSeq (mRNA)NM_001243186NM_008842
RefSeq (protein)NP_001230115NP_032868
Location (UCSC)Chr 6:
37.14 – 37.14 MbChr 17:
29.49 – 29.5 Mb
PubMed search[1][2]
This box: view talk edit
Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene.[1][2][3]
Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by the Moloney murine leukemia virus.[4] Subsequently, the oncogene has been implicated in multiple human cancers, including prostate cancer, acute myeloid leukemia and other hematopoietic malignancies.[5] Primarily expressed in spleen, thymus, bone marrow, prostate, oral epithelial, hippocampus and fetal liver cells, Pim-1 has also been found to be highly expressed in cell cultures isolated from human tumors.[4] Pim-1 is mainly involved in cell cycle progression, apoptosis and transcriptional activation, as well as more general signal transduction pathways.[4]
Contents [hide]
1 Gene
2 Protein structure
3 Activation and stabilization
4 Interactions
4.1 Activates
4.2 Deactivates
5 Clinical implications
6 References
7 Further reading
Gene [edit]

Located on chromosome 6 (6p21.2), the gene encompasses 5Kb of DNA, including 6 exons and 5 introns. Expression of Pim-1 has been shown to be regulated by the JAK/STAT pathway. Direct binding of